Table 1.
Main characteristics of the studies included in the meta-analysis of the association between brain-derived neurotrophic factor rs6265 and migraine.
| Reference | Country | Eligible participants | Migraine type, MO/MA | Age, mean (SD) in years | Detection method | rs6265 genotypes | MAF | HWE | Quality score | |
|---|---|---|---|---|---|---|---|---|---|---|
| Cases (M/F) | Controls (M/F) | Cases/controls | Group: GG/GA/AA | Cases/controls | p-Value Cases/controls | |||||
| Marziniak et al. (18) | Germany | 265 (43/222) | 153 (43/110) | 143/122 | 43.6 (13)/64.5 (9.4) | PCR-RFLP | Cases: 148/104/13 | 0.245/0.239 | 0.33/0.75 | 9 |
| MO: 80/57/6 | ||||||||||
| MA: 68/47/7 | ||||||||||
| Controls: 88/57/8 | ||||||||||
| Lemos et al. (19) | Portugal | 188 (35/153) | 287 (70/217) | 111/77 | 36.1 (12.8)/36.4 (12.5) | Real-time PCR | Cases: 118/64/6 | 0.202/0.197 | 0.45/0.43 | 11 |
| Controls: 183/95/9 | ||||||||||
| Sutherland et al. (20) | Australia | 857 (196/661) | 857 (196/661) | 212/645 | 43.7 (13.1)/44.8 (13.3) | PCR-RFLP | Cases: 396/193/23 | 0.195/0.172 | 0.93/0.87 | 10 |
| MO: 95/44/5 | ||||||||||
| MA: 311/149/18 | ||||||||||
| Controls: 544/224/24 | ||||||||||
| Coskun et al. (21) | Turkey | 288 (137/151) | 288 (133/155) | 176/112 | 31.3 (10.3)/31.5 (8.9) | Real-time PCR | Cases: 196/84/8 | 0.174/0.132 | 0.78/0.99 | 10 |
| MO: 121/49/6 | ||||||||||
| MA: 75/35/2 | ||||||||||
| Controls: 217/66/5 | ||||||||||
| Azimova et al.a (25) | Russia | 90 (14/76) | 363 (165/198) | 74/15 | 40.0 (12.0)/37.2 (8.7) | PCR-RFLP | Cases: 58/29/2 | 0.185/0.140 | 0.46/0.97 | 8 |
| MO: 48/24/2 | ||||||||||
| MA: 10/5/0 | ||||||||||
| Controls: 266/87/7 | ||||||||||
HWE, Hardy–Weinberg equilibrium; MAF, minor allele frequency; MO, migraine without aura; MA, migraine with aura; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism.
aData have been provided by the corresponding author himself after being contacted.