Table 3.
Summary of meta-analyses for the association of brain-derived neurotrophic factor rs6265 with migraine risk.
| Group or subgroup | No. studies | Sample size |
Odds ratio (95% confidence interval) | p | Heterogeneity |
Egger’s p | |
|---|---|---|---|---|---|---|---|
| Cases/controls | p (Q-test) | I2(%) | |||||
| Allelic model (A vs G) | |||||||
| Any migraine | 5 | 2884/3760 | 1.17 (1.03–1.34) | 0.014 | 0.60 | 0 | 0.75 |
| MO | 4 | 1074/3186 | 1.20 (0.99–1.44) | 0.057 | 0.56 | 0 | |
| MA | 4 | 1454/3186 | 1.17 (0.99–1.38) | 0.057 | 0.83 | 0 | |
| Higher quality | 3 | 2176/2734 | 1.18 (1.02–1.37) | 0.027 | 0.46 | 0 | |
| Lower quality | 2 | 708/1026 | 1.16 (0.88–1.54) | 0.30 | 0.29 | 12 | |
| Dominant model (GA + AA vs GG) | |||||||
| Any migraine | 5 | 1442/1880 | 1.22 (1.05–1.41) | 0.011 | 0.63 | 0 | 0.72 |
| MO | 4 | 537/1593 | 1.24 (0.99–1.54) | 0.051 | 0.67 | 0 | |
| MA | 4 | 717/1593 | 1.22 (1.00–1.47) | 0.047 | 0.76 | 0 | |
| Higher quality | 3 | 1088/1367 | 1.21 (1.02–1.44) | 0.028 | 0.49 | 0 | |
| Lower quality | 2 | 354/513 | 1.23 (0.90–1.68) | 0.20 | 0.29 | 11 | |
| Recessive model (AA vs GA + GG) | |||||||
| Any migraine | 5 | 1442/1880 | 1.18 (0.79–1.76) | 0.42 | 0.95 | 0 | 0.90 |
| MO | 4 | 537/1593 | 1.21 (0.68–2.16) | 0.52 | 0.73 | 0 | |
| MA | 4 | 727/1593 | 1.20 (0.73–1.98) | 0.47 | 0.99 | 0 | |
| Higher quality | 3 | 1088/1367 | 1.25 (0.79–1.99) | 0.34 | 0.84 | 0 | |
| Lower quality | 2 | 354/513 | 0.99 (0.45–2.16) | 0.97 | 0.82 | 0 | |
MO, migraine without aura; MA, migraine with aura.
p Values <0.05 are in boldface.