Figure 1.

Analysis of mice behavior in the open field test. Open field test was used to detect self-independent exploring ability and environmental adaptability. A circular open field consisted of 25 transparent areas at the peripheral, central, and intermediary of the arena. Mice were placed in the center of the open field and allowed to explore for 3 min. (A) Times of cross areas. (B) Times of upright. (C) Immobility time in the central area (latency). (n = 10; mean ± SD; One-way ANOVA followed by LSD multiple comparison tests; ^**p < 0.01 vs. WT group, ^##p < 0.01 vs. WT+SFN group, Δp < 0.05 and ΔΔp < 0.01 vs. AD group).