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SFN prevented from increasing the expression of HDACs mRNA and protein in the cerebral cortex of AD model mice. The relative expression of HDAC1, HDAC2 and HDAC3 mRNA (β-actin as a reference standard) (A) and protein (B,C) were analyzed by qRT-PCR and Western blot, respectively. (n = 10; mean ± SD; One-way ANOVA followed by LSD multiple comparison tests; **p < 0.01 vs. WT group, ##p < 0.01 vs. WT + SFN group, Δp < 0.05, ΔΔp < 0.01 vs. AD group).
