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. 2017 May 1;11:243. doi: 10.3389/fnins.2017.00243

Figure 3.

Figure 3

Intraperitoneal injection of BRL-44408 maleate can reverse the decrease of NE release induced by CUMS. (A) The dialysate concentration of NE were less in the first and third hour in the CUMS rats than that in the control rats, intraperitoneal injection of BRL-44408 maleate increased extracellular level of NE in both group of rats, but no significance was observed between the two groups. (B) The CUMS significantly decreased the mean levels of extracellular NE in the PVN of the CUMS rats compared to that in the control rats, but no significance was observed between the two groups after BRL-44408 maleate. (C) The ratio of increase in the NE release was significantly amplified after administration of BRL-44408 maleate in the CUMS rats compared to that in the control rats. The ratio: [(after-before)/before BRL-44408 maleate]. Δ: BRL-44408 maleate administration (3 mg/kg, i.p.). *p < 0.05 vs. the control rats. NS represents no significance.