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. 2017 May 1;11:243. doi: 10.3389/fnins.2017.00243

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Copyright © 2017 Wang, Wang, Wu, Huang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intraperitoneal injection of BRL-44408 maleate can reverse the increase of α_2A-AR induced by CUMS in the hypothalamus of the CUMS rats. (A.B) The protein expression levels of α_2A-AR was significantly increased in the hypothalamus of the CUMS rats, peripheral administration of BRL-44408 maleate significantly decreased the expression levels of α_2A-AR in the CUMS rats. ^*p < 0.05 vs. the control rats. ^#p < 0.05 vs. before BRL-44408 maleate in the CUMS group. NS represents no significance.