Table 4. Univariate analysis of the predicted risk factors for the need of exchange transfusion in 1,129 newborns with indirect hyperbilirubinemia.
| Variable | Exchange transfusion | Total | 95% CI | P value* | |
|---|---|---|---|---|---|
| Yes (n=49) | No (n=1,080) | ||||
| Male sex | 26 (53) | 620 (57) | 1,129 | - | 0.6 |
| Age at presentation (day) | 3.6 (2) | 4.4 (4) | 1,121 | −0.3 to −2 | 0.1 |
| Length of hospitalization (day) | 5.8 (3) | 3.2 (4) | 1,120 | −3.7 to −1.5 | <0.0001 |
| Hemoglobin (g/dL) | 15.6±2.6 | 16.7±2.4 | 1,108 | 0.4 to 1.8 | 0.002 |
| Hematocrit (%) | 46±7 | 49±7 | 675 | 0.6 to 6.3 | 0.02 |
| Reticulocyte count (%) | 4 (4) | 3 (2) | 988 | −2 to 0.4 | 0.2 |
| G6PD deficiency | 29 (62) | 413 (41) | 1,046 | - | 0.006 |
| ABO incompatibility | 19 (39) | 113 (42.3) | 316 | - | 0.8 |
| Rh incompatibility | 4.0 (8) | 9 (3.4) | 316 | - | 0.1 |
| Positive DCT | 5 (11.6) | 90 (9.2) | 1,023 | - | 0.6 |
| Total bilirubin at admission (µmol/L) | 438±121 | 283±63 | 689 | −206 to −106 | <0.0001 |
| Maximal bilirubin level (µmol/L) | 478±128 | 310±61 | 1,126 | −205 to −131 | <0.0001 |
| Positive urine culture | 2 (4.1) | 46 (4.3) | 247 | - | 0.4 |
| Positive blood culture | 12 (25) | 3 (0.4) | 175 | - | <0.0001 |
Values are presented as number (%) or mean±standard deviation.
G6PD, glucose 6 phosphate uridyltransferase enzyme; CI, confidence interval; ABO, blood group A, B, and O; Rh, rhesus factor; DCT, direct Coombs' test.
*Student t test was used for continuous variables and chi-square or Fisher exact test were used for categorical variables.