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. 2017 May 1;8:449. doi: 10.3389/fimmu.2017.00449

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Copyright © 2017 Speckmann, Sahoo, Rizzi, Hirabayashi, Karow, Serwas, Hoemberg, Damatova, Schindler, Vannier, Boulton, Pannicke, Göhring, Thomay, Verdu-Amoros, Hauch, Woessmann, Escherich, Laack, Rindle, Seidl, Rensing-Ehl, Lausch, Jandrasits, Strahm, Schwarz, Ehl, Niemeyer, Boztug and Wlodarski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical features of index patient 1 (P1). (A–C) Leukoplakia (<), sinistral cerebral hypoplasia (arrow). (D) Granulation tissue of tongue and (E) esophageal ulcers. (F) Apoptotic bodies in colon (arrows). (G) Hypocellular bone marrow before hematopoietic stem cell transplantation with immature erythropoiesis (arrow) and sparse myeloid precursors (triangle). (D–F) Hematoxylin and eosin staining, (G) naphthol-AS-d-chloroacetate esterase (NACE) staining.