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. 2017 May 1;8:449. doi: 10.3389/fimmu.2017.00449

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Copyright © 2017 Speckmann, Sahoo, Rizzi, Hirabayashi, Karow, Serwas, Hoemberg, Damatova, Schindler, Vannier, Boulton, Pannicke, Göhring, Thomay, Verdu-Amoros, Hauch, Woessmann, Escherich, Laack, Rindle, Seidl, Rensing-Ehl, Lausch, Jandrasits, Strahm, Schwarz, Ehl, Niemeyer, Boztug and Wlodarski.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impaired proliferative capacity of B-cell progenitors in vivo and CD34⁺ cells in vitro. (A) Normal ontogeny of B-cells in bone marrow (BM). B Prec, B-cell precursors; CLP, common lymphoid progenitor; HSC, hematopoietic stem cells; ImmB, Immature B-cells. (B) B-cell differentiation is markedly impaired in BM of P1 during severe adenovirus infection. CLP/ProB subsets are greatly reduced while B cell precursors are missing. (C) Between infectious intervals, all populations recover. (D,E) Total and CD34⁺ selected HSC from P3 and P5 fail to expand in non-differentiating culture. Ctrl, healthy control.