Scheme 2. Synthesis of N-Dansyl-Cys-DAP (4).
(i) Piperidine (20%) in DMF, rt, 15 min; (ii) dansyl chloride, DCM, DIPEA, rt, 3 h; (iii) DCC, ethyl acetate, rt, 2 h; (iv) DAP, DMF, rt, overnight; and (v) TFA/TIS (95:5), rt, 30 min.
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