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Chronic Inhibition of BET protein function prevented enhancements in BET protein genomic occupation. (a/b) ChIP revealed that treatment with JQ1 blocked Brd2 (a) and Brd4 (b) enhancements 30 mins following L-DOPA treatment (c/d) Repeated JQ1 treatment blocked the LID dependent effects on histone H3 phosphoacetylation (c) and histone H4K16 acetylation (Unpaired t-test; n=6–7 per group). Error bars represent SEM. *p<0.05 for treatment effect.
