Table 3.
Brain morphometry differences based on microbiota profiles
| IBS 1-HC-like IBS | |||||
|---|---|---|---|---|---|
| Brain area | Region of interest | Brain measure | p value | β value | Standard error |
| Somatosensory network | |||||
| pINS | Left posterior ramus of the lateral sulcus | SA | .002 | 60.73 | 18.47 |
| pINS | Right inferior segment of the circular sulcus of the insula | SA | .005 | 41.00 | 13.89 |
| pINS | Right inferior segment of the circular sulcus of the insula | V | .005 | 120.31 | 41.20 |
| pINS | Left posterior ramus of the lateral sulcus | V | .015 | 117.42 | 46.39 |
| pINS | Right long insular gyrus and central sulcus of the insula | MC | .045 | −0.01 | 0.01 |
| Basal ganglia | Right globus pallidus | V | .007 | 102.28 | 36.47 |
| Motor | Left superior part of the precentral sulcus | CT | .009 | −0.06 | 0.02 |
| Motor | Right superior part of the precentral sulcus | V | .006 | −246.50 | 84.96 |
| Motor | Right superior part of the precentral sulcus | SA | .017 | −96.24 | 39.02 |
| Motor | Right superior part of the precentral sulcus | CT | .026 | −0.06 | 0.03 |
| Motor | Right subcentral gyrus (central operculum) and sulci | CT | .020 | −0.08 | 0.03 |
| aINS | Left anterior segment of the circular sulcus of the insula | CT | .024 | −0.09 | 0.04 |
| aINS | Right anterior segment of the circular sulcus of the insula | CT | .029 | −0.13 | 0.06 |
| aINS | Right anterior segment of the circular sulcus of the insula | SA | .004 | 45.65 | 15.12 |
| aINS | Right anterior segment of the circular sulcus of the insula | V | .044 | 79.04 | 38.16 |
| IBS1 - HC | |||||
| pINS | Left long insular gyrus and central sulcus of the insula | V | .009 | 81.33 | 30.10 |
| pINS | Left long insular gyrus and central sulcus of the insula | SA | .011 | 20.87 | 7.93 |
| pINS | Right superior segment of the circular sulcus of the insula | CT | .045 | −0.05 | 0.02 |
| pINS | Left superior segment of the circular sulcus of the insula | CT | .042 | −0.05 | 0.02 |
| aINS | Right anterior segment of the circular sulcus of the insula | CT | .003 | −0.16 | 0.05 |
| aINS | Right anterior segment of the circular sulcus of the insula | SA | .002 | 43.67 | 13.51 |
| Somatomotor | Left central sulcus | CT | .043 | 0.04 | 0.02 |
| Somatomotor | Right central sulcus | CT | .033 | 0.04 | 0.02 |
| HC-like IBS - HC | |||||
| Somatosensory | Left postcentral sulcus | CT | .005 | 0.06 | 0.02 |
| Somatosensory | Right postcentral sulcus | CT | .011 | 0.05 | 0.02 |
| Somatomotor | Right central sulcus | CT | .009 | 0.05 | 0.02 |
| Somatomotor | Left central sulcus | CT | .018 | 0.04 | 0.02 |
| pINS | Right inferior segment of the circular sulcus of the insula | V | .001 | −122.97 | 35.48 |
| pINS | Right inferior segment of the circular sulcus of the insula | SA | .031 | −28.23 | 12.75 |
| pINS | Right inferior segment of the circular sulcus of the insula | CT | .022 | −0.07 | 0.03 |
| pINS | Left posterior insula gyrus | CT | .037 | 0.08 | 0.04 |
| pINS | Left long insular gyrus and central sulcus of the insula | MC | .035 | 0.01 | 0.01 |
| pINS | Right long insular gyrus and central sulcus of the insula | MC | .011 | 0.01 | 0.01 |
| pINS | Left posterior ramus of the lateral sulcus | SA | .034 | −37.78 | 17.27 |
| Basal ganglia | Right nucleus accumbens | V | .029 | −39.23 | 17.45 |
This table contains results of the contrast analysis within the framework of the general linear model. Contrast were coded based on the three level cluster factor; IBS1-HC-like IBS (1 -1 0), IBS1-HC (1 0 -1), HC-like IBS-HC (0 1 -1). As such positive beta values indicate greater values in the first group listed. Negative values reflect greater value in the second group
Abbreviations: INS anterior insula, pINS posterior insula, CT cortical thickness, SA surface area, V volume, MC mean curvature