TABLE 2.
Risk of Stomach Cancer by Radiation Dose to the Specific Stomach Tumor Location for Each First Cancer and for Combined Data
| Stomach tumor dose (Gy) | Cases/controls | Mean dose (Gy) | OR (95% CI) | Cases/controls | Mean dose (Gy) | OR (95% CI) | Cases/controls | Mean dose (Gy) | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| First cancer: | Hodgkin lymphoma | Testicular cancer | Cervical cancer | ||||||
| 0–0.19a | 5a/15 | 0.07 | 1.0 | 4a/29 | 0.0 | 1.0 | 28/71 | 0.003 | 1.0 |
| 0.2–1.99 | 13/52 | 0.9 | 1.1 (0.27, 4.4) | 0/4 | 0.8 | 5.3b (0.93, 37) | 110/191 | 1.2 | 1.5 (0.90, 2.6) |
| 2–4.99 | 4/12 | 2.9 | 1.6 (0.20, 12) | 6/7 | 3.8 | 43/96 | 2.8 | 1.1 (0.55, 2.1) | |
| 5–24.99 | 3/15 | 15.0 | 1.3 (0.19, 8.0) | 20/43 | 16.3 | 4.0 (1.2, 19) | 9/9 | 7.3 | 3.8 (1.1, 16) |
| 25–34.99 | 5/10 | 31.4 | 2.1 (0.35, 14) | 23/45 | 29.9 | 9.0 (2.3, 49) | 0/1 | 30.4 | 3.9 (0.62, 31) |
| 35–39.99 | 10/16 | 37.8 | 5.1 (1.1, 28) | 14/19 | 36.8 | 14.4 (3.2, 87) | 0/0 | – | |
| 40–59.1 | 8/15 | 42.7 | 2.8 (0.56, 15) | 19/27 | 45.7 | 16.4 (3.6, 98) | 3/1 | 42.1 | |
| Missing dose | 1/7 | 0.56 (0.02, 5.5) | 6/6 | 8.9 (1.6, 60) | 8/9 | 2.7 (0.83, 8.8) | |||
| P trendc | 0.011 | <.001 | .061 | ||||||
| EOR/Gy (95% CI) | 0.049 (0.007, 0.16) | .27 (0.054, 1.44) | .096 (−0.002, 0.39) | ||||||
| Combined first cancers: | Hodgkin lymphoma, testicular cancer, cervical cancer | Hodgkin lymphoma, testicular cancer | |||||||
| 0–0.19 | 37/115 | 0.012 | 1.0 | 9a/44 | 0.028 | 1.0 | |||
| 0.2–1.99 | 123/247 | 1.1 | 1.6 (0.98–2.5) | 13/56 | 0.87 | 1.8 (0.58–5.7) | |||
| 2–4.99 | 53/115 | 2.9 | 1.3 (0.74–2.4) | 10/19 | 3.29 | 4.8 (1.2–21) | |||
| 5–24.99 | 32/67 | 14.4 | 2.4 (1.2–4.8) | 23/58 | 15.99 | 2.6 (0.98–7.2) | |||
| 25–34.99 | 28/56 | 30.2 | 3.6 (1.6–8.3) | 28/55 | 30.17 | 4.8 (1.7–14) | |||
| 35–39.99 | 24/35 | 37.3 | 6.6 (2.9–16.0) | 24/35 | 37.26 | 8.1 (2.8–25) | |||
| 40–59.1 | 30/43 | 44.6 | 6.1 (2.7–14.2) | 27/42 | 44.69 | 7.5 (2.6–23) | |||
| P trendc | <0.001 | <0.001 | |||||||
| EOR/Gy (95% CI) | 0.091 (0.036–0.20) | .090 (0.032–0.22) | |||||||
Note. CI = confidence interval; OR = odds ratio; EOR = excess odds ratio.
a
The referent group of <0.2 Gy was chosen to ensure that there were at least 3 informative cases in the referent group for each first cancer. For both Hodgkin lymphoma and testicular cancer, there were 3 informative cases in the referent group.
b
Odds ratio for the combined dose category, 0.2–4.99 Gy.
c
Based on analyses that considered dose as a continuous linear variable.