TABLE 4.

Radiation Dose Response for Two Latency Windows (<20 and ≥20 years) Based on Patients from Hodgkin Lymphoma, Testicular Cancer and Cervical Cancer Studies

Stomach tumor dose (Gy)	Lateincy <20 years			Latency ≥20 years			All latencies
	Cases/controlsb	Mean dose	OR (95% CI)	Cases/controlsb	Mean dose	OR (95% CI)	Cases/controls	OR (95% CI)
0–0.19a	27/83	0.016	1.0	11/34	0.003	1.0	37/115	1.0
>0.2–4.99	114/211	1.62	1.6 (0.96, 2.7)	64/153	1.74	1.4 (0.66, 3.2)	176/362	1.5 (0.95, 2.4)
5–24.99	14/48	14.75	1.0 (0.4, 2.5)	17/19	14.01	13.0 (3.8, 54)	32/67	2.5 (1.2, 5.1)
25–34.99	17/41	30.28	2.1 (0.82, 5.7)	11/15	29.91	16.8 (4.1, 81)	28/56	3.8 (1.7, 8.8)
>35	35/47	40.55	5.0 (2.2, 11.5)	19/31	42.49	17.9 (4.9, 77)	54/78	6.5 (3.1, 14.0)
P trendc, d			<0.001			<0.001		<0.001

Note. CI = confidence interval; OR = odds ratio.

^aCases and controls without any radiation dose in the specified windows were allocated according to the two latency groups by the length of the interval between first and second cancer diagnoses.

^bNumbers of cases and controls with nonzero radiation doses in the specified window. Patients could have radiation dose included in both the <20 and >20 year windows.

^cTo evaluate trends with time since exposure, we used the year of the first annual radiation dose that exceeded 5 Gy or the date of the first dose, for patients who never received an annual dose of 5 Gy or more. See Supplementary Materials (http://dx.doi.org/10.1667/RR14453.1.S1) for additional details on the trend tests.

^dA four-degrees-of-freedom test for homogeneity of the categorical OR by latency yields P = 0.0024.