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. 2017 Apr 10;114(17):E3507–E3515. doi: 10.1073/pnas.1616232114

Fig. 6.

Fig. 6.

RPRFa increases excitability of ASIC3-expressing sensory neurons. (A) DRG neurons with ASIC3-like currents were recorded in current-clamp mode and repeatedly stimulated by superthreshold electrical stimuli (n = 3). Application of pH 6.3 slightly decreased excitability (Left) and additional preapplication of 50 μM RPRFa strongly decreased excitability (Right). (B) DRG neurons with ASIC3-like currents were repeatedly stimulated by subthreshold electrical stimuli (n = 3); pH 6.8 transiently increased excitability (Left) and additional preapplication of 10 μM RPRFa more persistently increased excitability (Right). (C, Top) Number of APs elicited by pH 6.3 in three DRG neurons with an ASIC3-like current, in the absence and the presence of 50 μM RPRFa. (C, Bottom) Number of APs elicited by pH 6.8 in three DRG neurons with an ASIC3-like current, in the absence and the presence of 10 μM RPRFa. Note that the number of current pulses varied from neuron to neuron. *P < 0.05 (Student’s t test).