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AlkZ sequence conservation. The sequence of S. sahachiroi AlkZ is aligned against seven orthologs chosen at random from the top 250 hits from a PSI-BLAST search. The secondary structure deduced from the crystal structure is shown at the top. Triangles designate Q37 and Q39 residues essential for catalysis (black), residues lining the concave active site cleft (gray), and residues predicted to contact DNA (white).
