Fig. 3.
PT and methylation site mapping across the E. coli HST04 genome. From outer to inner circles: Circles 1 and 2, (forward, reverse strands) 2,058 GPSATC sites in E. coli HST04 (dndBCDE) detected by SMRT in ORFs (black) and nonencoding regions (green). No site is detected in noncoding RNA. These sites were almost completely converted to methylation-PT double modification sites in E. coli HST04 (dndBCDE, dam). Circles 3 and 4, methylation sites E. coli HST04 (dndBCDE, dam) (excluding sites in circles 1 and 2) in ORFs (gray), noncoding RNA (blue), and nonencoding regions (red). Circles 5 and 6, predicted protein-coding sequences colored according to cluster of orthologous groups of proteins (COG) function categories. Circle 7, tRNA/rRNA operons. Circle 8, GC content. Circle 9, GC skew.