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. Author manuscript; available in PMC: 2018 May 4.
Published in final edited form as: Neuroscience. 2017 Feb 28;349:106–117. doi: 10.1016/j.neuroscience.2017.02.041

Figure 4. EZH2 inhibitors prevent the pain hypersensitivity induced by nerve injury.

Figure 4

(A) and (B) show the mean (± S.E.) mechanical withdrawal threshold and thermal withdrawal latency during the 10-day observation period in four groups of rats treated with daily intrathecal injection of either 20 nM DZNep (in 10 μL) or vehicle (10 μL) for 9 days. Comparisons between baseline and each time point in the pSNL+ vehicle group are indicated with *; comparisons between the pSNL + 20 nM DEZNep and pSNL + Vehicle groups are indicated with #. (C) and (D) show the mean (± S.E.) mechanical withdrawal threshold and thermal withdrawal latency during the 10-day observation period in five groups of rats treated with daily intrathecal injection of either 5 nM GSK-126 (in 10 μL), 0.5 nM GSK-126 (in 10 μL), or vehicle (10 μL) for 9 days. Comparisons between baseline and each time point in the pSNL+ vehicle group are indicated with *; comparisons between the pSNL + 5 nM GSK-126 and pSNL + Vehicle group are indicated with #; comparisons between the pSNL + 0.5 nM GSK-126 and pSNL + vehicle group are indicated with +. One symbol: p < 0.05; three symbols: p < 0.001.