Table 1.
Comparison of Humanized Mice and Nonhuman Primates for the In Vivo Evaluation of Cure Strategies
| Parameter | huMice | NHPs |
|---|---|---|
| Demonstrated HIV latency in T cells during ART | Yes | Yes |
| Tissue reservoirs similar to humans | Yes | Yes |
| Platform for testing treatment interruption and viral rebound | Yes | Yes |
| Platform for testing novel HIV induction (kick) strategies | Yes | Yes |
| Platform for testing novel HIV kill strategies Yes Yes | ||
| Anatomy similar to humans | No | Yes |
| Susceptibility to HIV infection | Yes | No |
| Susceptibility to SIV infection | No | Yes |
| T-cell responses to HIV | Yes | Yes |
| Modes of transmission routes similar to humans | Yes | Yes |
| Responsive to anti-HIV drugs used in humans | Yes | Yes /No |
| Responsive to anti-HIV antibodies | Yes | Yes |
Abbreviations: ART, antiretroviral therapy; HIV, human immunodeficiency virus; huMice, humanized mice; NHP, nonhuman primates; SIV, simian immunodeficiency virus.