Appendix Table 6.
Results according to Wald test of consistency under the restricted maximum likelihood (REML) and maximum likelihood (ML) estimators when applying all four effect measures. RD is the risk difference measure, RRH is the risk ratio for harmful outcomes, RRB is the risk ratio for beneficial outcomes and OR is the odds ratio.
| Design-by-treatment interaction approach | ||||||||
|---|---|---|---|---|---|---|---|---|
| OR | RRH | RRB | RD | |||||
| Network | REML Wald test (P value) | ML Wald test (P value) | REML Wald test (P value) | ML Wald test (P value) | REML Wald test (P value) | ML Wald test (P value) | REML Wald test (P value) | ML Wald test (P value) |
| Ades1 | 19.52 (<0.001) | 19.52 (<0.001) | 13.20 (0.004) | 18.32 (<0.001) | 22.63 (<0.001) | 22.63 (<0.001) | 22.03 (<0.001) | 22.03 (<0.001) |
| Ara2 | 1.76 (0.941) | 1.76 (0.941) | 1.75 (0.941) | 1.75 (0.941) | 1.11 (0.981) | 1.83 (0.935) | 2.41 (0.878) | 2.41 (0.878) |
| Baker3 | 16.02 (0.191) | 17.61 (0.128) | 25.02 (0.015) | 26.24 (0.01) | 15.13 (0.235) | 15.13 (0.235) | 11.70 (0.470) | 13.58 (0.328) |
| Ballesteros4 | 1.78 (0.776) | 3.20 (0.526) | 3.07 (0.547) | 4.36 (0.359) | 2.86 (0.582) | 6.06 (0.194) | 1.96 (0.744) | 3.57 (0.467) |
| Bangalore5 | 8.91 (0.882) | 14.36 (0.499) | 14.17 (0.513) | 20.49 (0.154) | 16.82 (0.330) | 16.83 (0.329) | 18.86 (0.220) | 18.86 (0.220) |
| Bansback6 | 2.16 (0.340) | 2.16 (0.340) | 2.22 (0.330) | 2.35 (0.310) | 7.15 (0.028) | 7.15 (0.028) | 1.30 (0.523) | 1.47 (0.480) |
| Bottomley7 | 5.65 (0.464) | 22.59 (0.001) | 6.92 (0.328) | 31.18 (<0.001) | 5.52 (0.479) | 16.89 (0.01) | 5.26 (0.511) | 24.90 (<0.001) |
| Brown8 | 5.77 (0.673) | 5.85 (0.664) | 5.50 (0.703) | 5.57 (0.695) | 5.45 (0.709) | 5.45 (0.709) | 5.91 (0.657) | 5.91 (0.657) |
| Bucher9 | 0.73 (0.695) | 0.73 (0.695) | 0.70 (0.706) | 0.70 (0.706) | 1.04 (0.594) | 1.35 (0.508) | 1.13 (0.567) | 1.49 (0.474) |
| Cipriani10 | 32.25 (0.504) | 32.25 (0.504) | 28.4 (0.696) | 37.04 (0.288) | 32.7 (0.482) | 38.85 (0.223) | 30.37 (0.599) | 39.72 (0.196) |
| Dias11 | 9.90 (0.449) | 12.78 (0.236) | 9.90 (0.449) | 12.60 (0.247) | 8.41 (0.589) | 11.49 (0.321) | 8.73 (0.558) | 12.18 (0.273) |
| Eisenberg12 | 2.65 (0.265) | 3.27 (0.195) | 3.19 (0.203) | 3.76 (0.153) | 3.23 (0.199) | 4.24 (0.120) | 3.09 (0.214) | 3.66 (0.161) |
| Elliott13 | 19.62 (0.105) | 31.70 (0.003) | 20.09 (0.093) | 31.27 (0.003) | 9.53 (0.732) | 31.78 (0.003) | 9.00 (0.773) | 32.33 (0.002) |
| Govan14 | 12.1 (0.017) | 12.1 (0.017) | 12.67 (0.013) | 12.67 (0.013) | 7.69 (0.104) | 8.23 (0.083) | 9.07 (0.059) | 9.50 (0.050) |
| Hofmeyr15 | 3.44 (0.179) | 3.44 (0.179) | 3.47 (0.177) | 3.47 (0.177) | 2.72 (0.257) | 2.92 (0.232) | 2.72 (0.256) | 2.94 (0.230) |
| Imamura16 | 26.84 (0.140) | 26.84 (0.140) | 11.16 (0.934) | 33.17 (0.032) | 21.71 (0.357) | 23.56 (0.262) | 15.85 (0.726) | 45.81 (0.001) |
| Lam17 | 2.92 (0.404) | 2.92 (0.404) | 2.78 (0.427) | 2.78 (0.427) | 0.21 (0.977) | 0.57 (0.904) | 0.16 (0.983) | 0.35 (0.949) |
| Lapitan18 | 6.06 (0.195) | 6.49 (0.166) | 5.85 (0.211) | 5.85 (0.211) | 8.97 (0.062) | 8.97 (0.062) | 9.49 (0.050) | 9.49 (0.050) |
| Lu (1)19 | 5.11 (0.647) | 6.76 (0.455) | 4.57 (0.713) | 5.87 (0.555) | 5.19 (0.637) | 6.97 (0.432) | 5.64 (0.582) | 7.48 (0.381) |
| Lu (2)19 | 11.19 (0.083) | 6.06 (0.195) | 11.86 (0.065) | 14.53 (0.024) | 10.32 (0.112) | 13.92 (0.031) | 12.05 (0.061) | 16.76 (0.010) |
| Macfayden 22 | 12.20 (0.032) | 20.74 (0.001) | 15.23 (0.009) | 15.23 (0.009) | 0.00 (<0.001) | 27.22 (<0.001) | 3.69 (0.595) | 14.38 (0.013) |
| Middleton23 | 2.17 (0.141) | 2.17 (0.141) | 1.90 (0.168) | 1.90 (0.168) | 2.76 (0.097) | 2.76 (0.097) | 2.87 (0.091) | 2.87 (0.091) |
| Mills24 | 1.75 (0.782) | 2.02 (0.732) | 3.14 (0.535) | 3.53 (0.473) | 1.14 (0.889) | 1.29 (0.863) | 1.94 (0.746) | 2.19 (0.700) |
| Nixon25 | 7.45 (0.059) | 29.51 (<0.001) | 14.92 (0.002) | 21.76 (<0.001) | 5.09 (0.165) | 28.05 (<0.001) | 12.37 (0.006) | 39.33 (<0.001) |
| Picard26 | 60.43 (0.001) | 101.29 (<0.001) | 60.67 (0.001) | 127.27 (<0.001) | 50.24 (0.016) | 50.24 (0.016) | 62.85 (0.001) | 123.81 (<0.001) |
| Playford27 | 1.52 (0.218) | 1.52 (0.218) | 1.49 (0.222) | 1.49 (0.222) | 0.94 (0.333) | 0.94 (0.333) | 0.81 (0.369) | 1.11 (0.291) |
| Psaty28 | 10.71 (0.38) | 13.62 (0.191) | 5.99 (0.816) | 10.32 (0.413) | 10.21 (0.423) | 18.10 (0.053) | 9.64 (0.473) | 16.76 (0.080) |
| Puhan29 | 6.13 (0.525) | 7.15 (0.413) | 8.52 (0.289) | 8.52 (0.289) | 6.37 (0.498) | 9.51 (0.218) | 6.49 (0.418) | 8.19 (0.316) |
| Roskell (1)31 | 4.54 (0.337) | 8.03 (0.090) | 4.54 (0.337) | 8.23 (0.084) | 3.56 (0.469) | 5.66 (0.226) | 3.45 (0.486) | 5.86 (0.210) |
| Roskell (2)30 | 0.20 (0.906) | 0.20 (0.906) | 1.31 (0.520) | 1.31 (0.520) | 0.51 (0.776) | 0.51 (0.776) | 0.82 (0.663) | 0.82 (0.663) |
| Salliot32 | 11.81 (0.003) | 11.81 (0.003) | 2.74 (0.254) | 2.76 (0.252) | 10.44 (0.005) | 13.34 (0.001) | 5.11 (0.078) | 5.11 (0.078) |
| Sciarretta33 | 12.99 (0.449) | 22.25 (0.052) | 14.33 (0.351) | 14.33(0.351) | 42.75 (<0.001) | 42.75 (<0.001) | 50.80 (<0.001) | 50.80 (<0.001) |
| Soares-Weiser34 | 1.94 (0.963) | 7.97 (0.336) | 1.33 (0.988) | 21.62 (0.003) | 2.86 (0.898) | 7.17 (0.411) | 1.91 (0.965) | 12.62 (0.082) |
| Thijs35 | 1.66 (0.893) | 1.66 (0.893) | 1.87 (0.867) | 1.87 (0.867) | 1.61 (0.9) | 1.91 (0.861) | 1.64 (0.896) | 1.86 (0.868) |
| Trikalinos36 | 0.73 (0.393) | 0.73 (0.393) | 0.68 (0.411) | 0.68 (0.411) | 0.01 (0.905) | 0.01 (0.906) | 0.04 (0.850) | 0.04 (0.850) |
| Virgili37 | 0.09 (0.759) | 0.13 (0.714) | 0.01 (0.910) | 0.01 (0.910) | 2.39 (0.122) | 2.39 (0.122) | 1.50 (0.221) | 1.59 (0.207) |
| Wang38 | 5.71 (0.574) | 8.46 (0.294) | 5.64 (0.582) | 8.76 (0.270) | 6.21 (0.515) | 8.01 (0.331) | 6.05 (0.534) | 8.28 (0.309) |
| Welton39 | 4.14 (0.845) | 4.48 (0.812) | 4.01 (0.857) | 4.30 (0.829) | 6.33 (0.611) | 8.13 (0.420) | 6.57 (0.584) | 8.25 (0.410) |
| Woo40 | 5.59 (0.232) | 5.59 (0.232) | 2.13 (0.711) | 3.51 (0.477) | 10.69 (0.030) | 24.39 (<0.001) | 4.89 (0.299) | 8.10 (0.088) |
| Yu41 | 3.28 (0.858) | 3.28 (0.858) | 3.27 (0.859) | 3.27 (0.859) | 2.71 (0.910) | 2.71 (0.910) | 2.82 (0.901) | 2.82 (0.901) |