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. 2017 May 1;12(5):e0176185. doi: 10.1371/journal.pone.0176185

Fig 4. ROC curve and AUC values from the simulated data at a fold-change of 1.5 and 2.

Fig 4

Illustrated are the ROC curves for detecting 1, 500 DEGs (750 up and 750 dow-regulated) using a fold change = 1.5 (A) and a fold change = 2 (B) with an unequal library size. Calculated AUC values are in the inset. The simulated data, containing a total of 15,000 genes in two conditions and 10 replicates per condition, was used for evaluating the performance of eight normalization methods. Our methods (UQ-pgQ2 and Med-pgQ2) are in cyan and blue, respectively.