Table 1. Summary of normalization methods and software packages on different datasets for DEGs analysis.
| Normalization methods | Datasets | Statistical test | Software packages |
|---|---|---|---|
| TC | MAQC and simulated data | Exact test | edgeR(v3.8.6) |
| Med | MAQC and simulated data | Exact test | edgeR (v3.8.6) |
| UQ | MAQC and simulated data | Exact test | edgeR (v3.8.6) |
| FQ | MAQC and simulated data | Exact test | edgeR (v3.8.6) |
| TMM | MAQC and simulated data | Exact test | edgeR (v3.8.6) |
| Med-pgQ2 | MAQC and simulated data | Exact test | edgeR (v3.8.6) |
| UQ-pgQ2 | MAQC and simulated data | Exact test | edgeR (v3.8.6) |
| DESeq | MAQC and simulated data | Wald test | DESeq2 (v1.6.3) |
| FPKM | MAQC | t-test | Cufflinks-cuffdiff2 (v2.2.1) |