Table 2. Cross tabulation of intNMF cluster subtypes with (i) Expression cluster subtypes [44] and (ii) iCluster subtypes [37] using Glioblastoma data.
The summary table, followed by cross tabulation, represents somatic mutations in a few genes (highlighted by previous studies [44, 45]) presented as percentage of their presence in each of the three integrative clusters. Graphical representation of this table has been provided with S8 Fig.
| intNMF | Total | ||||
|---|---|---|---|---|---|
| C1 | C2 | C3 | |||
| Expression Subtype | Classical | 2 | 0 | 12 | 14 |
| Messenchymal | 12 | 0 | 4 | 16 | |
| Neural | 6 | 0 | 2 | 8 | |
| Proneural | 1 | 12 | 4 | 17 | |
| Total | 21 | 12 | 22 | 55 | |
| iCluster | C1 | 1 | 0 | 19 | 20 |
| C2 | 1 | 12 | 0 | 13 | |
| C3 | 19 | 0 | 3 | 22 | |
| Total | 21 | 12 | 22 | 55 | |
| Somatic Mutation | TP53 (%) | 30 | 66.7 | 31.8 | |
| NF1 (%) | 30 | 16.7 | 4.5 | ||
| PTEN (%) | 25 | 8.3 | 31.8 | ||
| EGFR (%) | 5 | 8.3 | 31.8 | ||
| PIK3R1 (%) | 0 | 25 | 18.2 | ||
| PIK3CA (%) | 0 | 8.3 | 9.1 | ||
| RB1 (%) | 15 | 0 | 4.5 | ||
| ERBB2 (%) | 15 | 16.7 | 9.1 | ||