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. 2017 Apr 19;13(4):e1006352. doi: 10.1371/journal.ppat.1006352

Fig 2. R-909 specifically infects HER2-pos cells.

Fig 2

(A) Both the R-909 and the non-detargeted R-903 infect cells that express HER2 as the sole receptor (J-HER2 cells). J cells express no receptor for wt-HSV. J-HER2, J-nectin1 and J-HVEM express only the indicated receptor. The pattern of infection of R-909 is similar to that of R-809, and differs from that of R-LM5. (B) R-909, but not R-903, specifically infects HER2-pos, and fails to infect the HER2-neg cancer cells. In all panels, the indicated cells were infected at 3 PFU/cell. Infection was monitored at 24 h by fluorescence microscopy.