Figure 2.

(A) Dendrogram showing the separation of all erythrocyte microRNA profiles into 2 large groups. While HbSS and normal (HbAA, NL) are clearly separated, the samples of PNH are separated into 2 distinct clusters termed HbSS-like PNH or NL-like PNH. The HbSS-like and NL-like PNH correspond to before and after eculizumab treatment. (B) Heatmap of the expression of erythrocyte microRNAs that separate the samples with microRNA clustering corresponding to NL-like, HbSS-like and PNH, which are shown and further expanded in (C)