Table 1.
Summary of experimental pain (pharmacodynamic) assessment results after single- and multiple-dose administrations of DWP05195 to healthy male subjects
| Dose group | ΔHPtrnorm,3h | ΔHPtrcap,3h | ΔHPtolnorm,3h | ΔHPtolcap,3h |
|---|---|---|---|---|
| Single dose | ||||
| Placebo (n=16) | 0.6±2.0 | – | −0.1±0.9 | – |
| 10 mg (n=8) | 0.4±2.9 | – | 0.8±1.3 | – |
| 20 mg (n=8) | −1.2±3.7 | – | −0.5±1.4 | – |
| 50 mg (n=8) | 1.1±1.7 | – | 0.9±0.8 | – |
| 100 mg (n=8) | 2.1±1.8 | – | 1.3±0.9 | – |
| 150 mg (n=8) | 1.0±1.8 | – | 0.9±1.1 | – |
| 250 mg (n=8) | 2.5±1.9 | – | 1.4±1.2 | – |
| 400 mg (n=8) | 2.0±2.9 | – | 1.2±1.0 | – |
| 600 mg (n=8) | 3.3±3.3 | – | 1.5±1.4 | – |
| Multiple dose | ||||
| Placebo (n=8) | 1.9±4.4 | 1.0±1.0 | 1.4±1.5 | 2.3±1.8 |
| 100 mg (n=8) | 0.8±3.5 | 2.9±2.8 | 0.9±0.9 | 2.8±2.5 |
| 200 mg (n=8) | 2.9±2.1 | 5.1±2.2 | 2.6±1.2 | 3.5±1.9 |
| 300 mg (n=8) | 6.0±3.0 | 2.6±2.8 | 3.9±2.6 | 3.5±2.4 |
| 400 mg (n=8) | 2.2±1.5 | 2.3±3.5 | 1.4±1.5 | 4.4±2.9 |
Abbreviations: HPtrnorm, heat pain threshold in normalized skin; HPtrcap, heat pain threshold in capsaicin-sensitized skin; HPtolnorm, heat pain tolerance in normalized skin; HPtolcap, heat pain tolerance in capsaicin-sensitized skin.