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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Mech Ageing Dev. 2017 Feb 27;162:27–37. doi: 10.1016/j.mad.2017.02.006

Fig. 1.

Fig. 1

Methylation patterns in (A) C1ql3 (full gene shown) and (B) Srd5a2 (only 5′ region shown). The 5′ regions of both genes harbor CpG islands (CGI; shown as green block) that undergo progressive increase in methylation with age (Bonferroni p < 0.05). Number of mice per age group are young = 4, mid = 4, old = 3. Combined read coverage is depicted for young (yellow), mid (green), and old mice (maroon). Horizontal bars below the coverage map show the aligned read fragments. These CGIs are conserved in humans and are targeted by CpG probes in the Illumina Infinium HumanMethylation450K BeadChips. Most show significant positive correlation with age in human liver tissue and correlation between age and example probes for C1QL3 (Pearson R = 0.66, p-value < 0.0001) (C) and SRD5A2 C1QL3 (Pearson R = 0.44, p-value < 0.0001) (D) are shown.