Table 3.

Mouse-human comparison of age-DMRs

Gene	Mouse mm10	Human hg191	Conservation (mm10-hg19)1	CGI?2	#450K probes3	Protein Factors (ENCODE data) 4
C1QL3	chr2:13010001-13010500	chr10:16,562,204-16,562,717	100.0% bases, 100.0% span	5′UTR, Exon1 CGI	8	EZH2, RBBP5, CTBP2, CTCF
SRD5A2	chr17:74047001-74048000	chr2:31,805,006-31,806,119	95.8% bases, 100.0% span	5′UTR, Exon1 CGI	8	EZH2, TBP
PTK7	chr17:46628501-46629500	chr6:43044006-43045132	96.0% bases, 100.0% span	5′UTR, Exon1 CGI	5	CHD2, CTBP2, E2F1, EGR1, ELF1, HDAC1, HDAC2, HDAC6, HMGN3, JUN, JUND, MXI1, PHF8, POLR2A, RAD21, RBBP5, REST, RFX5, SIN3A, SIN3AK20, SP1, TAF1, TBP, UBTF, YY1, ZBTB7A, ZNF143
ZFAND3	chr17:30116501-30117000	na	Not conserved	na	na	na
RFX4	chr10:84759501-84760500	chr12:106980246-106981266	92.9% bases, 100.0% span	Intron1 CGI	9	EZH2, SUZ12, RBBP5
SND1	chr6:28832501-28833000	chr7:127671585-127672065	95.6% bases, 100.0% span	Intron CGI	9	RBBP5, CHD1, RUNX3, SUZ12, POLR2A, E2F1, CTCF, RAD21, SIN3AK20, FOS, GATA2, TAF1, MAFK
SERPINA1B	chr12:103728001-103728500	chr14:94844558-94845035	92.4% bases, 100.0% span	Last exon, 3′UTR	1	POLR2A
APOA1	chr2:13010001-13010500	chr11:116706431-116706931	98.4% bases, 100.0% span	Last exon, 3′UTR CGI	4	POLR2A, JUND, RBBP5, PHF8, PML, TAF1, HMGN3, KAP1, REST, ZNF263, CCNT2, TCF7L2, MAX, CTBP2, E2F6, MYC, MXI1, ELF1, FOXM1, SP1, NRF1, PAX5, TCF3, E2F4, TRIM28, BACH1, GABPA, MAZ, ZBTB7A, FOXP2, BHLHE40, HDAC6, YY1, SRF, IRF4, CTCF, TCF12, GATA3, ZNF143, RUNX3, RCOR1, SMC3, RAD21, CTCFL, CBX3, NR3C1, ESR1

¹Sequence conservation between mouse reference genome (mm10) and human reference genome (hg19)

²Gene features and whether site overlaps CpG island (CGI) or not

³Number of probes in the Illumina Infinium HumanMethylation450 BeadChips that map to the conserved region

⁴Protein factors that bind to the age-DMRs; data from transcription factor ChIP-seq for 161 factors generated by ENCODE Consortium for human cell lines