Table 2.
Peptide transporters in bacterial pathogens.
| Peptide substrates | Bacterial pathogen | Role in virulence | |
|---|---|---|---|
| PTR peptide transporters | |||
| Tpp | Tripeptides | Salmonella Typhimurium | Antimicrobial resistance58 |
| CstA | Dipeptides & Tripeptides | Salmonella Typhimurium | Virulence in Caenorhabditis elegans62 |
| YjiY | Dipeptides & Tripeptides | Salmonella Typhimurium | Induction of class III flagellar genes andvirulence in Balb/c mouse model13 |
| DtpT | Dipeptides & Tripeptides | Staphylococcus aureus | Unknown |
| ABC peptide transporters | |||
| Opp operon | Oligopeptides | Salmonella sp | Unknown |
| Mycobacterium tuberculosis | Glutathione import for methyl glyoxal detoxification, Induction of cytokine release and apoptosis in macrophages68 | ||
| Staphylococcus aureus | Bacteremia54 | ||
| Corynebacterium pseudotuberculosis | Adhesion to host cells15 | ||
| Clostridium difficile | Sporulation and virulence in hamster model55 | ||
| Listeria monocytogenes | Survival inside macrophages56 | ||
| Campylobacter jejuni | Growth inside host66 | ||
| Moraxella catarhhalis | Fitness inside host65 | ||
| Borrelia burgdorferi | Infectivity in mouse model70 | ||
| Dpp operon | Dipeptides | Salmonella Typhimurium | Chemotaxis30 |
| Streptococcus pyogenes | Expression of cysteine protease52 | ||
| Ami operon | Oligopeptides | Streptococcus pneumoniae | Survival inside human saliva and transmission49,50 |
| App operon | Oligopeptides | Clostridium difficile | Sporulation and virulence in hamster model55 |
| Yej operon | Oligopeptides | Salmonella Typhimurium | Antimicrobial resistance63 |
| Sap operon | Oligopeptides | Salmonella Typhimurium | Antimicrobial resistance64 |
| HppA | Hexapeptides | Streptococcus gordonii | Adhesion to host51 |