Table 3.
Person-time: Association between age, CD4 count and viral load and antiretroviral status
| CD4 count, cells/μL a | Viral load / ARV status b | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| <200 | 200–499 | ≥500 | Suppressive ARVs | Non-suppressive cART | No ARVs | |
| Age, years | ||||||
| 7–12 | 19.2 (2%) | 139.8 (11%) | 1084.1 (87%) | 958.6 (77%) | 239.5 (19%) | 45.1 (4%) |
| 13–17 | 129.3 (5%) | 558.9 (23%) | 1,770.4 (72%) | 1,726.1 (70%) | 587.3 (24%) | 145.2 (6%) |
| 18–30 | 515.7 (18%) | 898.5 (32%) | 1,431.7 (50%) | 1,607.3(56%) | 983.6 (35%) | 255.0 (9%) |
| 18–21 | 276.7 (15%) | 592.4 (31%) | 1,018.1 (54%) | 1,087.0 (58%) | 648.6 (34%) | 151.6 (8%) |
| 22–25 | 202.3 (25%) | 263.0 (33%) | 340.8 (42%) | 426.2 (53%) | 291.0 (36%) | 89.1 (11%) |
| 26–30 | 36.6 (24%) | 43.1 (28%) | 72.8 (48%) | 94.2 (62%) | 44.1 (29%) | 14.3 (9%) |
| Viral load/ARV status c | ||||||
| Suppressive ARVs | 95.4 (2%) | 699.2 (16%) | 3,497.4 (81%) | |||
| Non-suppressive cART | 460.4 (25%) | 704.7 (39%) | 645.3 (36%) | |||
| No ARVs | 108.5 (24%) | 193.3 (43%) | 143.5 (32%) | |||
Row percents are presented.
Proportion of person-time with CD4 count <200 cells/μL according to age: Relative difference (95% confidence interval): 13–17 vs. 7–12 years: 4% (2 – 5%); 18–21 vs. 7–12 years: 13% (10 – 16%); 22–25 vs. 7–12 years: 24% (19 – 28%); 26–30 vs. 7–12 years: 22% (13 – 31%); p<0.001 for all comparisons.
Proportion of person-time with VL ≥400 copies/mL according to age: Relative difference (95% confidence interval): 13–17 vs. 7–12 years: 7% (3 – 11%); 18–21 vs. 7–12 years: 20% (15 – 24%); 22–25 vs. 7–12 years: 24% (18 – 30%); 26–30 vs. 7–12 years: 15% (5 – 25%); p<0.01 for all comparisons. The median frequency of HIV RNA measurements during follow-up for subjects while aged 7–12, 13–17, 18–21, 22–25, and 26–30 years was every 3.6, 3.5, 3.9, 4.3, and 4.3 months, respectively.
Proportion of person-time with CD4 count <200 cells/μL according to VL/ARV status: Relative difference (95% confidence interval): suppressive ARVs vs. no ARVs: −22% (−28 – −17%), p<0.001, non-suppressive cART vs. no ARVs: 1% (−5 – 7%), p=0.72. (Similar results were seen for the outcome of CD4 count <500/μL.)
ARV, antiretroviral; cART, combination antiretroviral therapy