Table 2.
Significant changes in gene expression during AVF maturation (day 7) compared to the control veins (microarray data): metabolic pathways (p<0.05).
| Pathway | Gene Symbol | Full name | Fold- change |
|---|---|---|---|
| Oxidative phosphorylation | NDUFV1 | NADH dehydrogenase (ubiquinone) flavoprotein 1 |
−2.9 |
| CYC1 | cytochrome c-1 | −2.9 | |
| UQCRFS1 | ubiquinol-cytochrome c reductase, Rieske iron- sulfur polypeptide 1 |
−2.7 | |
| UQCRC1 | ubiquinol-cytochrome c reductase core protein 1 |
−2.7 | |
| NDUFS1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1 |
−2.6 | |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 |
−2.6 | |
| COX Va | cytochrome c oxidase subunit Va | −2.6 | |
| UQCR 10 | ubiquinol-cytochrome c reductase, complex III subunit X |
−2.5 | |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 |
−2.4 | |
| NDUFA9 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 |
−2.4 | |
| NDUFS6 | NADH dehydrogenase (ubiquinone) Fe-S protein 6 |
−2.4 | |
| NDUFA10 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10 |
−2.3 | |
| NDUFS3 | NADH dehydrogenase (ubiquinone) Fe-S protein 3 |
−2.3 | |
| Succinate dehydrogenase | −2.2 | ||
| NDUFB6 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 |
−2.2 | |
| UQCR11 | ubiquinol-cytochrome c reductase, complex III subunit XI |
−2.2 | |
| NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5 |
−2.2 | |
| NDUFS2 | NADH dehydrogenase (ubiquinone) Fe-S protein 2 |
−2.2 | |
| NDUFB9 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 |
−2.2 | |
| NDUFS8 | NADH dehydrogenase (ubiquinone) Fe-S protein 8 |
−2.1 | |
| ATP5A | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha |
−2.1 | |
| NDUFS7 | NADH dehydrogenase (ubiquinone) Fe-S protein 7 |
−2.1 | |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein |
−2.1 | |
| NDUFA4 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4 |
−2.1 | |
| Cytochrome C | −2.0 | ||
| NDUFB5 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 |
−2.0 | |
| COX Vb | cytochrome c oxidase subunit Vb | −2.0 | |
| Mitochondrial long chain fatty acid beta-oxidation | CPT-1B | carnitine palmitoyltransferase 1b, muscle | −5.9 |
| ACADVL | acyl-CoA dehydrogenase, very long chain | −4.0 | |
| HADHB | hydroxyacyl-CoA dehydrogenase/3-ketoacyl- CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit |
−3.3 | |
| ACAA2 | acetyl-CoA acyltransferase 2 | −3.1 | |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 |
−2.8 | |
| Acetyl-CoA acyltransferase |
−2.7 | ||
| ECHS1 | enoyl CoA hydratase, short chain, 1, mitochondrial |
−2.7 | |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl- CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit |
−2.7 | |
| CPT2 | carnitine palmitoyltransferase 2 | −2.6 | |
| ACADM | acyl-Coenzyme A dehydrogenase, medium chain |
−2.4 | |
| HCDH | hydroxyacyl-Coenzyme A dehydrogenase | −2.3 | |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 |
−2.0 | |
| Mitochondrial unsaturated fatty acid beta-oxidation | HADHB | hydroxyacyl-CoA dehydrogenase/3-ketoacyl- CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit |
−3.3 |
| ACAA2 | acetyl-CoA acyltransferase 2 | −3.0 | |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 |
−2.8 | |
| Acetyl-CoA acyltransferase |
−2.7 | ||
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl- CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit |
−2.7 | |
| ECHS1 | enoyl CoA hydratase, short chain, 1, mitochondrial |
−2.7 | |
| DCI | enoyl-CoA delta isomerase 1 | −2.5 | |
| ACADM | acyl-Coenzyme A dehydrogenase, medium chain |
−2.4 | |
| HCDH | mitochondrial hydroxyacyl-coenzyme a dehydrogenase |
−2.3 | |
| ACSL1 | acyl-CoA synthetase long-chain family member 1 |
−2.0 | |