Table 2. Health outcomes by patient subpopulation (per 10,000 patients).
Cases of: | Treatment naïve non-cirrhotic | Treatment naïve cirrhotic | Treatment experienced non-cirrhotic | Treatment experienced cirrhotic | ||||
2nd Gen DAA | 1st Gen DAA + not treated | 2nd Gen DAA | 1st Gen DAA + not treated | 2nd Gen DAA | 1st Gen DAA + not treated | 2nd Gen DAA | 1st Gen DAA + not treated | |
Hepatic decompensation | - | 1,990.8 | 1,533.9 | 3,883.7 | 326.9 | 2,211.4 | 1,444.0 | 4,143.4 |
Hepatocellular carcinoma | 23.7 | 1,493.3 | 1,397.7 | 2,771.4 | 264.6 | 1,656.2 | 1,345.2 | 2,923.2 |
Liver transplantation | - | 273.9 | 229.4 | 592.5 | 44.2 | 304.2 | 215.8 | 632.6 |
Liver-related death | 20.5 | 2,718.6 | 2,417.4 | 5,506.9 | 456.4 | 3,017.4 | 2,302.3 | 5,847.9 |
Life years | 19.5 | 17.9 | 17.3 | 14.6 | 19.2 | 17.7 | 17.4 | 14.3 |
Quality adjusted life years | 16.2 | 14.1 | 13.8 | 11.0 | 16.0 | 13.9 | 13.9 | 10.6 |
1st Gen DAA, first generation direct-acting antiviral agents; 2nd Gen DAA, second generation direct-acting antiviral agents. Analysis only includes patients with hepatitis C genotype 1. Results are presented per 10,000 patients.