Table 1.

Randomization schedule for the Dog Aging Project Rapamycin Intervention Phase I Trial

Dog no.	Randomized treatment group	Dog no.	Randomized treatment group	Dog no.	Randomized treatment group
1	placebo	11	placebo	21	0.1 mg/kg
2	0.05 mg/kg	12	0.1 mg/kg	22	0.1 mg/kg
3	0.05 mg/kg	13	0.1 mg/kg	23	0.1 mg/kg
4	0.05 mg/kg	14	placebo	24	0.1 mg/kg
5	placebo	15	0.1 mg/kg	25	placebo
6	0.05 mg/kg	16	0.1 mg/kg	26	0.1 mg/kg
7	0.05 mg/kg	17	placebo	27	0.1 mg/kg
8	0.05 mg/kg	18	0.1 mg/kg	28	0.1 mg/kg
9	0.05 mg/kg	19	0.1 mg/kg	29	placebo
10	0.05 mg/kg	20	placebo

The dogs were randomized into the study in chronological order following the first exam upon determination that they met the study criteria, including no significant pre-existing conditions. The study medication was allocated at the corresponding dose according to the dog weight at the first visit, and the owners were given instructions to provide the study medication three times each week on Monday, Wednesday, and Friday in the morning. The owners and study staff, with the exception of the clinic director, were blinded to the randomization groups