Table 2.
Group | Breed | Sex | Age (years) | Weight (kg) |
---|---|---|---|---|
Placebo | Standard poodle | FS | 9.7 | 21 |
Placebo | Mixed breed | MN | 10 | 44 |
Placebo | Mixed breed | MN | 6.6 | 31 |
Placebo | Mixed breed | FS | 7.2 | 25 |
Placebo | Labrador retriever | FS | 6.8 | 26 |
Placebo | Mixed breed | MN | 8.3 | 27 |
Placebo | Great Dane | FS | 10.4 | 37 |
Placebo | Mixed breed | MN | 7.5 | 33 |
Low | Mixed breed | MN | 8.8 | 34 |
Low | Mixed breed | FS | 12.7 | 34 |
Low | Golden retriever | FS | 12 | 31 |
Low | English bulldog | MN | 7.2 | 34 |
Low | Mixed breed | FS | 10.8 | 31 |
High | Golden retriever | FS | 9.2 | 31 |
High | Mixed breed | FS | 8 | 36 |
High | Wheaten terrier | MN | 8.3 | 22 |
High | Labrador retriever | MI | 7.9 | 34 |
High | Chow | FS | 9.6 | 23 |
High | Mixed breed | FS | 11.5 | 22 |
High | Doberman | FS | 6.8 | 24 |
High | Labrador retriever | MN | 11.1 | 38 |
High | Labrador retriever | FS | 8 | 36 |
High | Mixed breed | MN | 6.8 | 31 |
Higha | Mixed breed | MN | 11.1 | 29 |
The breed indicates owner-reported information. Age is owner-reported age at the time of the first exam, verified by age indicated on veterinary records. The weight is the measured weight at the first exam
Sex is indicated as follows, verified at initial exam. FS female spayed, FI female intact, MN male neutered, MI male intact
aA dog that was randomized to the high rapamycin group and completed the entire 10-week study, but it was discovered upon reviewing the dosing log that the owners had mistakenly provided the dog with 0.025 mg/kg rapamycin three times each week. This dog was removed from analysis of the high rapamycin group, but was included in analysis of the pooled (low and high dose) rapamycin-treated dogs