Table 3.

Owner-reported symptoms and changes in behavior

Symptom/behavioral change	Placebo (%)	Low rapa (%)	High rapa (%)
Increased water consumption	3 (38)	1 (20)	4 (40)
Fatigue/lethargy	1 (13)	1 (20)	3 (30)
Vomiting	2 (25)	2 (40)	2 (20)
Diarrhea	3 (38)	1 (20)	4 (40)
Cough	2 (25)	1 (20)	3 (30)
Skin irritation/rash	2 (25)	2 (40)	2 (20)
Lipoma	1 (13)	0 (0)	0 (0)
Limping/slipping	2 (25)	2 (40)	0 (0)
Constipation	1 (13)	0 (0)	0 (0)
Eye irritation	1 (13)	0 (0)	1 (10)
Increased appetite	1 (13)	2 (40)	0 (0)
Decreased appetite	1 (13)	0 (0)	0 (0)
Weight loss	1 (13)	0 (0)	0 (0)
Increased energy	2 (25)	2 (40)	7 (70)
More affectionate	0 (0)	2 (40)	2 (20)
Increased alertness	0 (0)	0 (0)	1 (10)

Symptoms and changes in behavior reported by owners during the 10 weeks that their dog participated in the study. The number of different dogs within each treatment for which a particular symptom or change in behavior was reported at least once during the study is shown with the percentage of dogs shown in parentheses