Fig. 3.
IGF-1 deficiency beginning earlier in life extends female lifespan. a Survival curve analysis of 121 control (black), 39 LID10d (red), 44 LID5m (green), and 38 LID15m (blue) male mice. Lifespan extension was assessed using the average median lifespan (b) and the average maximal lifespan (c, remaining 10% survival) of male mice in the various treatment groups. d Survival curves of 130 control (black), 38 LID10d (red), 43 LID5m (green), and 45 LID15m (blue) female mice. Lifespan extension was assessed using the average median lifespan (e) and the average maximal lifespan (f, remaining 10% survival) of female mice in the various treatment groups. The age of cancer-induced mortality (relative to total cancer-induced deaths) was plotted for male (g) and female (h) mice. Sixty-three percent of all deaths were induced by cancer. The asterisks indicate a significant difference compared to control animals (p < 0.05)