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Central role of the adipocyte in multisystem disease. Abbreviations: AT1/AT2, angiotensin II receptor type I/II; GLUT4, glucose transporter type 4; IRS1/2, insulin receptor substrate 1/2; MCP-1, monocyte chemoattractant protein 1; NO, nitric oxide; PAI-1, plasminogen activator inhibitor 1; PPAR-γ, peroxisome proliferator-activated receptor-γ; TNF-α, tumor necrosis factor α. Adapted with permission from Macmillan Publishers Ltd, Kidney Int 2008;74(7):851–3.
