Table 2.
Anticonvulsant activity of the tested compounds in the 6-Hz test following i.p. administration in mice (dose of 100 mg/kg)
| Cmpd | 6-Hz test | |||
|---|---|---|---|---|
| 0.25 h | 0.5 h | 1 h | 2 h | |
| 4 | 3/4 | 3/4 | 3/4 | 2/4 |
| 5 | 4/4 | 4/4 | 3/4 | 0/4 |
| 8 | 4/4 | 4/4 | 2/4 | 2/4 |
| 9 | 4/4 | 4/4 | 2/4 | 0/4 |
| 15 | 4/4 | 3/4 | 0/4 | 0/4 |
| 16 | 2/4 | 4/4 | 0/4 | 0/4 |
Data indicate number of mice protected/number of mice tested. Ratios where at least two animals were protected have been highlighted in italics for easier data interpretation. The animals were examined at four pretreatment times: 0.25, 0.5, 1, and 2 h