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The quantitative pharmacological parameters ED50 values in the 6-Hz test following i.p. administration in mice
| Compound | TPE (h) |
ED50
(mg/kg) |
|---|---|---|
| 4 | 0.25 | 24.66 (18.13–33.55) |
| 5 | 0.25 | 31.97 (19.66–51.98) |
| 8 | 0.25 | 33.79 (12.79–89.29) |
| 9 | 0.25 | 40.49 (24.26–67.58) |
| 15 | 0.25 | 38.75 (23.48–63.94) |
| 16 | 0.5 | 47.21 (34.29–65.02) |
| Valproic acid | 0.5 | 130.64 (117.61–145.19) |
| Lacosamide | 0.5 | 5.25 (3.55–7. 76) |
TPE time to peak effect
