Table 1.
Cell-surface markers of cells involved in murine eosinophilopoiesis.
| Common myeloid progenitor | Granulocyte and macrophage progenitor | Eosinophil precursor (EoPre) | EoP | Mature Eo | |
|---|---|---|---|---|---|
| Lineage | − | − | higha | − | ND |
| Sca-1 | − | − | − | − | − |
| c-Kit | + | high | − | low | − |
| CD34 | + | + | − | + | − |
| FcγRII/III | low | high | ND | ND | ND |
| IL-5Rα | − | − | + | + | + |
| IL-3R | ND | + | ND | ND | + |
| IL-4Rα | ND | ND | ND | ND | + |
| GM-CSFR | ND | + | ND | ND | + |
| Siglec-F | ND | ND | low | + | + |
| CCR3 | ND | ND | ND | ND | + |
| Granularity (SSC) | low | low | low | high | high |
| ST2 | +/− | +/− | − | + | + |
+ indicates expression; − indicates no expression; ND indicates expression not determined.
aUnlike other studies, this study included CD11b in the lineage cocktail and demonstrated that the EoPre is CD11bhi.