Table 1.

Reports observing the chronologic relationship between membranous nephropathy (MN) and anti-glomerular basement membrane (GBM) disease

Reference	Age/gender	Clinical presentation	Therapy	Outcome
Group 1
Klassen et al. [4]	49/M	Edema, chest pain, anuria	Steroids	Died of seizure
Moorthy et al., case 1 [5]	53/M	Edema	Steroids, azathioprine	Hemodialysis
Richman et al., case 1 [6]	65/M	Edema, renal failure	Steroids, CP, PP	Died of myocardial infarction
Kurki et al. [7]	54/M	Cough, arthralgia, pleurisy, nephritic	Steroids, PP	ESRD, transplant
Thitiarchakul et al. [8]	57/?	Edema, vomiting, shortness of breath, hemoptysis	Steroids, CP, PP	Hemodialysis
Nayak and Satish [9]	54/F	Edema, oliguria, vomiting	Steroids, CP, PP	Hemodialysis
Group 2
Agodoa et al. [10]	22/F	Cough, weakness, syncope, hematuria	None	Recovery
Savige et al., case 5 [11]	20/M	Hematuria	“Cytotoxic drugs,” PP	Recovery
Savige et al., case 6 [11]	18/F	Hematuria	PP, steroids, CP	Chronic kidney disease
Elder et al. [12]	20/M	Hemoptysis, dyspnea, fever, hematuria	Steroids, CP	Recovery, proteinuria
Keilstein et al. [13]	17/M	Hemoptysis, hematuria	Antibiotics	Recovery
Hecht et al. [14]	9/F	Abdominal pain, emesis, malaise, hematuria	Steroids, CP, PP, cyclosporine	Recovery
Group 3
Moorthy et al., case 2 [5]	44/M	Ankle edema	Steroids	Dialysis
Pasternack et al. [15]	19/F	Hemoptysis, hematuria	Steroids, azathioprine	Nephrectomy, dialysis
Sharon et al. [16]	25/M	Hemoptysis, hematuria, edema	Steroids, CP, PP	Died (pulmonary hemorrhage)
Richman et al., case 2 [6]	65/M	Hemoptysis	Steroids, azathioprine	Died (pulmonary hemorrhage)
Jennette et al. [17]	17/M	Sore throat, fever, minimal hemoptysis	Steroids, CP	Recovery
Tomaszewski et al. [18]	22/F	Hemoptysis, hematuria	NA	NA
Pettersson et al. [19]	20/M	Sore throat, fever, lumbar pain, hematuria	Steroids, PP	Recovery
Savige et al., case 1 [11]	16/F	Hemoptysis, hematuria, edema	Steroids, CP, PP	Recovery
Savige et al., case 2 [11]	47/M	History of hematuria, anuria	NA	Dialysis, transplant
Savige et al., case 3 [11]	21/M	Hematuria, hemoptysis	Steroids, CP, PP	Recovery
Savige et al., case 4 [11]	20/F	Hematuria, anemia	Steroids, CP, PP	Recovery
Hayano et al. [20]	60/M	Prolonged anorexia, general malaise	Steroids, PP	Dialysis
Takeuchi et al. [21]	70/M	Acute renal failure	Steroids, CP, PP	Died (unclear)
Meisels et al. [22]	50/M	Edema for 4 months, then hematuria	Steroids, CP, PP	Recovery
Sano et al. [23]	54/F	Hematuria, proteinuria, acute renal failure	Steroids, PP	Dialysis
Nasr et al. [24]	53/M	Cough, sore throat, fatigue, dyspnea, hematuria	Steroids, CP, PP	Dialysis
Singh et al. [25]	48/F	Anuria	Steroids, CP, PP	Dialysis
Hoshino et al. [26]	71/F	Fatigue, nausea, pitting edema, pulmonary edema	Steroids	Renal insufficiency
Troxell et al. [27]	49/M	Fatigue, hematuria, flank pain	Steroids, CP, PP	Dialysis
Cui et al. [28]	20/M	Hematuria, generalized edema	NA	Dialysis
Cui et al. [28]	40/M	Hematuria	Steroids, CP, PP	Dialysis
Cui et al. [28]	40/F	Upper respiratory tract infection, hematuria	Steroids, CP, PP	Renal insufficiency
Patel et al. [29]	59/M	Nausea, vomiting, renal insufficiency	Steroids, CP, PP	Dialysis
Basford et al. [30]	59/M	Fatigue, hematuria, acute renal failure	Steroids, CP, PP	Recovery
Present case	76/M	Fever, persistent cough, general fatigue, leg edema	Steroids, PP, entecavir	Renal insufficiency

Group 1 MN followed by anti-GBM disease, Group 2 primary anti-GBM disease followed by granular subepithelial deposits, Group 3 simultaneous detection of both lesions, M male, F female, CP cyclophosphamide, PP plasmapheresis, NA not available. Adapted from Basford et al. [30]