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. 2017 Apr 28;91(10):e01228-16. doi: 10.1128/JVI.01228-16

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FIG 3 — Mutant CAs are sensitive to REAF restriction. (A) Infection of HeLa-CD4-shREAF cells with HIV-1^{NL4.3 CA N74D} (MCR) renders it susceptible to REAF compared to the viral pseudotype with wild-type CA (HIV-1^NL4.3 [MCR]) (P < 0.001). (B to E) Titers of HIV-1^NL4.3 (MCR), HIV-1^{NL4.3 CA P38A} (MCR), HIV-1^{NL4.3 CA G89V} (MCR), and HIV-1^{NL4.3 CA G94D} (MCR) following a challenge of HeLa-CD4 and HeLa-CD4-shREAF cells. (F) Fold changes in HIV-1^{NL4.3 CA P38A} (MCR), HIV-1^{NL4.3 CA G89V} (MCR), and HIV-1^{NL4.3 CA G94D} (MCR) on HeLa-CD4-shREAF cells compared to wild-type CA (HIV-1^NL4.3 [MCR]) show that they are also susceptible to REAF (all P < 0.001 [*]).