TEM of BS-C-1 cells infected with VACV. The cells were infected with WT VACV WR (A), vΔA6 (B), vYLDV-97 (C), and chimeras 1 to 3 (D and E) at an MOI of 1 PFU per cell. Twenty-four hours after infection, the cells were fixed and prepared for TEM. C, crescent; V, viroplasm; IV, immature virion; IVN, IV with nucleoid.