FIG 11.

Ablation of Kupffer cells by clodronate liposomes increases the virus load and enhances pathogenicity more in the livers of Ad5-infected than in those of Ad6-infected hamsters. (A) Virus burdens in livers at 3 days postchallenge. (B) Serum alanine transaminase levels. PBS-Ad5 versus PBS-Ad6, P = 0.0244; clodronate-Ad5 versus clodronate-Ad6, P = 0.0012; PBS-Ad5 versus clodronate-Ad5, P = 0.0002; PBS-Ad6 versus clodronate-Ad6, P = 0.0004 (Mann-Whitney U test). Symbols signify values from individual animals; horizontal bars signify the mean value for each group. NQ, not quantifiable; ND, not detectable.