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. 2017 Apr 28;91(10):e00284-17. doi: 10.1128/JVI.00284-17

FIG 5.

FIG 5

Ad6 is more pathogenic than Ad5 in CP-treated hamsters. (A) Survival. Ad5 versus Ad6 at all dose levels, P < 0.0001 (Log rank). (B) Body weight changes. Each symbol represents the value from an individual animal. Ad5 versus Ad6 at all dose levels, P < 0.0001 (two-way ANOVA). (C) Serum alanine transaminase levels. Each symbol represents the value from an individual animal; the horizontal bars signify the mean value for each group. Ad5 versus Ad6 at 1.2 × 1011 PFU/kg, P = 0.0043; Ad5 versus Ad6 at 1.7 × 1011 PFU/kg, P = 0.0079; Ad5 versus Ad6 at 2 × 1011 PFU/kg, P = 0.0022 (Mann-Whitney U test). (C) Virus burdens in livers. Each symbol represents the value from an individual animal; the horizontal bars signify the mean value for each group. Ad5 versus Ad6 at all dose levels, P = 0.0022 (Mann-Whitney U test).