FIG 4.

Viral titers are elevated in the CNS of mice deficient for Ccr7. (A) Viral titers were quantified in the brain by FFU assay in WT and Ccr7^−/− mice. The dotted line indicates the assay's limit of detection. (B) Paraffin-embedded brain sections from WT and Ccr7^−/− mice on day 12 postinfection were stained for WNV (red) and nuclear 4′,6′-diamidino-2-phenylindole (DAPI; blue). Representative images are shown at a magnification of ×10, with zoomed-in insets. Data are shown as means ± standard deviations for n = 3 to 9 mice per genotype and time point from two independent experiments. **, P < 0.01.