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. 2017 Apr 28;91(10):e02076-16. doi: 10.1128/JVI.02076-16

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Copyright © 2017 Hinkula et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — (A to D) Th1 cytokine determination in serum samples collected after two (A2, B2, C2) and three (A3, B3, C3) immunizations before challenge, from the four groups (A, B, C, and D). Each of the four panels illustrates individual mouse serum levels and group geometric mean levels at 95% confidence intervals of IFN-γ, IL-2, IL-12p70, and TNF-α, respectively. (E to H) Th2 cytokine determination in serum samples collected after two (A2, B2, C2) and three (A3, B3, C3) immunizations but before challenge, from the four groups (A, B, C, and D). Each of the four panels illustrates individual mouse serum levels and group geometric mean levels at 95% confidence intervals of IL-4, IL-5, IL-10, and GM-CSF, respectively. A Mann-Whitney test was made for group-wise comparison, and a P value of <0.05 was considered significant. n.s., not significant.

FIG 3 — (A to D) Th1 cytokine determination in serum samples collected after two (A2, B2, C2) and three (A3, B3, C3) immunizations before challenge, from the four groups (A, B, C, and D). Each of the four panels illustrates individual mouse serum levels and group geometric mean levels at 95% confidence intervals of IFN-γ, IL-2, IL-12p70, and TNF-α, respectively. (E to H) Th2 cytokine determination in serum samples collected after two (A2, B2, C2) and three (A3, B3, C3) immunizations but before challenge, from the four groups (A, B, C, and D). Each of the four panels illustrates individual mouse serum levels and group geometric mean levels at 95% confidence intervals of IL-4, IL-5, IL-10, and GM-CSF, respectively. A Mann-Whitney test was made for group-wise comparison, and a P value of <0.05 was considered significant. n.s., not significant.