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. 2017 Apr 28;91(10):e02076-16. doi: 10.1128/JVI.02076-16

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Copyright © 2017 Hinkula et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 4 — (A to D) Cytokine determination in serum samples collected from two groups, A and B, of immunized mice postchallenge. An analysis is shown of levels of Th1-pattern cytokines prior to experimental CCHFV challenge. Each of the four panels illustrates individual mouse serum levels in duplicate and group geometric mean levels at 95% confidence intervals of IFN-γ, IL-2, IL-12p70, and TNF-α, respectively. (E to H) Cytokine determination in serum samples collected from two groups, A and B, of immunized mice postchallenge. An analysis is shown of levels of Th2-pattern cytokines postchallenge. Each of the four panels illustrates individual mouse serum levels in duplicate and group geometric mean levels at 95% confidence intervals of IL-4, IL-5, IL-10, and GM-CSF, respectively. A Mann-Whitney test was made for group-wise comparison, and a P value of <0.05 was considered significant.

FIG 4 — (A to D) Cytokine determination in serum samples collected from two groups, A and B, of immunized mice postchallenge. An analysis is shown of levels of Th1-pattern cytokines prior to experimental CCHFV challenge. Each of the four panels illustrates individual mouse serum levels in duplicate and group geometric mean levels at 95% confidence intervals of IFN-γ, IL-2, IL-12p70, and TNF-α, respectively. (E to H) Cytokine determination in serum samples collected from two groups, A and B, of immunized mice postchallenge. An analysis is shown of levels of Th2-pattern cytokines postchallenge. Each of the four panels illustrates individual mouse serum levels in duplicate and group geometric mean levels at 95% confidence intervals of IL-4, IL-5, IL-10, and GM-CSF, respectively. A Mann-Whitney test was made for group-wise comparison, and a P value of <0.05 was considered significant.