Table 1. PROMIS inclusion and exclusion criteria.

Patient inclusion criteria

Men at least 18 years or over at risk of prostate cancer who have been advised to have a prostate biopsy

Serum PSA ⩽15ng ml−1 within previous 3 months

Suspected stage ⩽T2 on rectal examination (organ confined)

Fit for general/spinal anaesthesia

Fit to undergo all protocol procedures including a transrectal ultrasound

Signed informed consent

Patient exclusion criteria

Treated using 5-alpha-reductase inhibitors at time of registration or during the prior 6 months

Previous history of prostate biopsy, prostate surgery or treatment for prostate cancer (interventions for BPH/bladder outflow obstruction are acceptable)

Evidence of a urinary tract infection or history of acute prostatitis within the last 3 months

Contraindication to MRI (e.g., claustrophobia, pacemaker, estimated GFR ⩽50)

Any other medical condition precluding procedures described in the protocol

Previous history of hip replacement surgery, metallic hip replacement or extensive pelvic orthopaedic metal work.

Abbreviations: GFR, glomerular filtration rate; MRI, magnetic resonance imaging.