Table 3. Results of analysis after interpolation.
| Variable | Primary analysis |
Secondary analysis |
||
|---|---|---|---|---|
| Definitions of CCL and heterogeneity | Separate count/Gleason grades | Separate count/Gleason score | Cumulative count/Gleason grades | Cumulative count/Gleason score |
| No. of independent lesions | 195 | 195 | 190 | 190 |
| Gleason score, no (±95% CI) | ||||
| 3+3 | 119 (61±6.9%) | 119 (61±6.9%) | 118 (62±6.9%) | 118 (62±6.9%) |
| 3+4 | 66 (34±6.6%) | 66 (34±6.6%) | 64 (34±6.7%) | 64 (34±6.7%) |
| 4+3 | 10 (5±3.1%) | 10 (5±3.1%) | 8 (4±2.9%) | 8 (4±2.9%) |
| Lesion volume, ml, median | 0.075 | 0.075 | 0.075 | 0.075 |
| IQR | (0.025–0.225) | (0.025–0.225) | (0.025–0.275) | (0.025–0.275) |
| Range | (0.025–6.200) | (0.025–6.200) | (0.025–8.275) | (0.025–8.275) |
| Homogeneous lesions, no. (±95% CI) | 148 (76±6.0%) | 152 (78±5.8%) | 144 (76±6.1%) | 148 (78±5.9%) |
| Heterogeneous lesions, no. (±95% CI) | 47 (24±6.0%) | 43 (22±5.8%) | 46 (24±6.1%) | 42 (22±5.9%) |
| Heterogeneous lesions with concordant hotspots, no. (±95% CI) | 36/47 (77±12.1%) | 33/43 (77±12.6%) | 34/46 (74±12.7%) | 33/42 (79±12.4%) |
| Heterogeneous lesions with no concordant hotspots, no. (±95% CI) | 11/47 (23±12.1%) | 10/43 (23±12.6%) | 12/46 (26±12.7%) | 9/42 (21±12.4%) |
| 3-D hotspots distance in heterogeneous non-concordant lesions, mm, median (IQR) | 12.8 (9.9–15.5) | 12.5 (9.9–15.8) | 11.5 (9.9–14.0) | 9.9 (9.8–15.3) |
| Total number of concordant lesions (±95% CI) | 184/195 (94±3.2%) | 185/195 (95±3.1%) | 178/190 (94±3.5%) | 181/190 (95±3.0%) |
Abbreviations: CCL, cancer core length; CI, confidence interval; IQR, interquartile range.